Procyclidine

Pronunciation: proe-SYE-kli-deen
Generic Name: Procyclidine
Brand Name: Kemadrin

Procyclidine is used for:

Treating Parkinson disease. It may also be used for other conditions as determined by your doctor.

Procyclidine is an anticholinergic agent. It works by relaxing smooth muscle, which stops muscle spasms.

Do NOT use Procyclidine if:

• you are allergic to any ingredient in Procyclidine


• you have angle-closure glaucoma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Procyclidine:

Some medical conditions may interact with Procyclidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have glaucoma, mental or mood disorders, muscle weakness (eg, myasthenia gravis), ulcerative colitis, (eg, an enlarged prostate), or urination problems


• if you have a blockage of the stomach, esophagus, or urinary tract; kidney or liver problems; high blood pressure; heart or blood vessel disease; an irregular heartbeat; or uncontrolled movements of the hands, mouth, or tongue

Some MEDICINES MAY INTERACT with Procyclidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Phenothiazines (eg, thioridazine) because the effectiveness may be decreased by Procyclidine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Procyclidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Procyclidine:

Use Procyclidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Procyclidine with food or immediately after finishing a meal.


• If you miss a dose of Procyclidine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Procyclidine.

Important safety information:

• Procyclidine may cause lightheadedness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Procyclidine. Using Procyclidine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Procyclidine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.


• Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.


• Use Procyclidine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Procyclidine, discuss with your doctor the benefits and risks of using Procyclidine during pregnancy. It is unknown if Procyclidine is excreted in breast milk. If you are or will be breast-feeding while you are using Procyclidine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Procyclidine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dilated pupils; dry mouth; giddiness; lightheadedness; loss of appetite; nausea; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; difficult or painful urination; difficulty swallowing; eye pain; fast or pounding heartbeat; mental or mood changes; uncontrolled movements.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Procyclidine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dilated pupils; fast breathing; fast heartbeat; hot, dry, or flushed skin.

Proper storage of Procyclidine:

Store Procyclidine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Procyclidine out of the reach of children and away from pets.

General information:

• If you have any questions about Procyclidine, please talk with your doctor, pharmacist, or other health care provider.


• Procyclidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Procyclidine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Procyclidine resources

• Procyclidine Side Effects (in more detail)
• Procyclidine Use in Pregnancy & Breastfeeding
• Procyclidine Drug Interactions
• Procyclidine Support Group
• 3 Reviews for Procyclidine - Add your own review/rating

• Procyclidine Professional Patient Advice (Wolters Kluwer)


• procyclidine Concise Consumer Information (Cerner Multum)


• Kemadrin Prescribing Information (FDA)


• Kemadrin Monograph (AHFS DI)

Compare Procyclidine with other medications

• Extrapyramidal Reaction
• Parkinson's Disease
• Parkinsonian Tremor
• Parkinsonism